Sodium Hydroxide → Diethyl-[4-(1H-indol-5-yloxy)-butyl]-amine

HRID 1633628노트

반응식

HRID 1633628 반응식
C(OC([N:8]1[C:16]2[C:11](=[CH:12][C:13]([O:17][CH2:18][CH2:19][CH2:20][CH2:21][N:22]([CH2:25][CH3:26])[CH2:23][CH3:24])=[CH:14][CH:15]=2)[CH:10]=[CH:9]1)=O)(C)(C)C.[OH-].[Na+]>CCO>[CH2:25]([N:22]([CH2:23][CH3:24])[CH2:21][CH2:20][CH2:19][CH2:18][O:17][C:13]1[CH:12]=[C:11]2[C:16](=[CH:15][CH:14]=1)[NH:8][CH:9]=[CH:10]2)[CH3:26]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 695488375-(4-Diethylamino-butoxy)-indole-1-carboxylic acid tert-butyl ester

생성물 1

HCID 18679455Diethyl-[4-(1H-indol-5-yloxy)-butyl]-amine수율 96%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

3.9 g (10.8 mmol) 5-(4-Diethylamino-butoxy)-indole-1-carboxylic acid tert-butyl ester in 4 ml EtOH were treated with 0.4 ml halfconc. NaOH at 60° C. for 2 h. The suspension was concentrated in vacuo and the residue dissolved in EtOAc and water. The organic phase was washed with water and dried over Na2SO4. Evaporation yielded 2.7 g (96%) Diethyl-[4-(1H-indol-5-yloxy)-butyl]-amine as brown oil, MS: 261 (MH+).

후처리

  1. concentrationThe suspension was concentrated in vacuo
  2. dissolutionthe residue dissolved in EtOAc
  3. washThe organic phase was washed with water
  4. dry with materialdried over Na2SO4
  5. customEvaporation

출처 및 근거

ORD 기록
ord-a70007d2915c45308cae53b33c0735f6
출처 데이터셋
uspto-grants-2003_01
특허 번호
US06503907B2

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