Ammonium Chloride → HCID 18679742, 화합물

HRID 1633716

반응식

HRID 1633716 반응식
I[C:2]1[N:3]=[CH:4][N:5]([S:7]([N:10]([CH3:12])[CH3:11])(=[O:9])=[O:8])[CH:6]=1.C([Mg]Br)C.[CH3:17][O:18][C:19]1[C:20]([N+:30]([O-:32])=[O:31])=[C:21]2[C:26](=[CH:27][CH:28]=1)[C:25](=[O:29])[CH2:24][CH2:23][CH2:22]2.[Cl-].[NH4+]>ClCCl>[OH:29][C:25]1([C:2]2[N:3]=[CH:4][N:5]([S:7]([N:10]([CH3:12])[CH3:11])(=[O:9])=[O:8])[CH:6]=2)[C:26]2[C:21](=[C:20]([N+:30]([O-:32])=[O:31])[C:19]([O:18][CH3:17])=[CH:28][CH:27]=2)[CH2:22][CH2:23][CH2:24]1

참가 물질

6

반응물 4

HCID 25517Ammonium ChlorideHCID 2773390N,N-Dimethyl 4-iodo-1H-imidazole-1-sulfonamideHCID 130673376-Methoxy-5-nitro-1,2,3,4-tetrahydronaphthalen-1-oneHCID 178418443HCID 178418443, 화합물

생성물 1

HCID 18679742HCID 18679742, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A solution of 4-iodo-N,N-dimethyl-1H-imidazole-1-sulfonamide (3.0 g, 10 mmol) (R. M. Turner, J. Org. Chem. (1991), 56, 5739-5740) in dichloromethane (40 mL) was treated with ethyl magnesium bromide (3.0M in diethyl ether, 3.3 mL) over 5 minutes, stirred for 30 minutes, treated with 6-methoxy-5-nitro-1-tetralone (2.6 g, 11.8 mmol), stirred for 16 hours, treated with ammonium chloride solution and extracted with dichloromethane. The extract was dried (MgSO4), filtered and concentrated to provide the desired compound.

후처리

  1. stirringstirred for 16 hours
  2. extractionextracted with dichloromethane
  3. dry with materialThe extract was dried (MgSO4)
  4. filtrationfiltered
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-ef094213dff74786b4547236844aa51b
출처 데이터셋
uspto-grants-2003_01
특허 번호
US06503935B1

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