Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ammonium Chloride → HCID 18679742, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ammonium Chloride | HCID 25517 | — |
| 반응물 | N,N-Dimethyl 4-iodo-1H-imidazole-1-sulfonamide | HCID 2773390 | — |
| 반응물 | 6-Methoxy-5-nitro-1,2,3,4-tetrahydronaphthalen-1-one | HCID 13067337 | — |
| 반응물 | HCID 178418443 | HCID 178418443 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | HCID 18679742 | HCID 18679742 | — |
반응 단계
A solution of 4-iodo-N,N-dimethyl-1H-imidazole-1-sulfonamide (3.0 g, 10 mmol) (R. M. Turner, J. Org. Chem. (1991), 56, 5739-5740) in dichloromethane (40 mL) was treated with ethyl magnesium bromide (3.0M in diethyl ether, 3.3 mL) over 5 minutes, stirred for 30 minutes, treated with 6-methoxy-5-nitro-1-tetralone (2.6 g, 11.8 mmol), stirred for 16 hours, treated with ammonium chloride solution and extracted with dichloromethane. The extract was dried (MgSO4), filtered and concentrated to provide the desired compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06503935B1 |
| 출처 데이터셋 | uspto-grants-2003_01 |
| ORD ID | ord-ef094213dff74786b4547236844aa51b |
| 출처 메모 | uspto-grants-2003_01 |