Aniline → 2H-Benzimidazol-2-one, 1,3-dihydro-1-phenyl-

HRID 1634023

반응식

HRID 1634023 반응식
F[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N+:8]([O-])=O.[NH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.[C:18]([O-])([O-])=[O:19].[K+].[K+]>CC#N>[C:3]1([N:8]2[C:13]3[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=3[NH:11][C:18]2=[O:19])[CH:4]=[CH:5][CH:6]=[CH:7][CH:2]=1

참가 물질

5

반응물 3

HCID 6115AnilineHCID 11430Potassium CarbonateHCID 738951-Fluoro-2-nitrobenzene

생성물 1

HCID 846572H-Benzimidazol-2-one, 1,3-dihydro-1-phenyl-

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

2-fluoronitrobenzene was treated with aniline in the prescence of K2CO3 in CH3CN and heated to reflux for 12 h. The solution is cooled, filtered and the solvent removed. The nitro group is reduced with catalytic hydrogenation and the diamine treated with CDI to give 1-phenyl-1,3-dihydro-benzoimidazol-2-one.

후처리

  1. temperatureheated
  2. temperatureto reflux for 12 h
  3. temperatureThe solution is cooled
  4. filtrationfiltered
  5. customthe solvent removed
  6. additionthe diamine treated with CDI

출처 및 근거

ORD 기록
ord-6ce79da2204742599c88902fe82d6331
출처 데이터셋
uspto-grants-2003_01
특허 번호
US06506738B1

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