Hydrogen Bromide → 5-(Bromomethyl)-1H-indazole--hydrogen bromide (1/1)

HRID 1634156노트

반응식

HRID 1634156 반응식
C([N:4]1[C:12]2[C:7](=[CH:8][C:9]([CH2:13]OC(=O)C)=[CH:10][CH:11]=2)[CH:6]=[N:5]1)(=O)C.[BrH:18]>>[BrH:18].[Br:18][CH2:13][C:9]1[CH:8]=[C:7]2[C:12](=[CH:11][CH:10]=1)[NH:4][N:5]=[CH:6]2

참가 물질

3

반응물 2

HCID 260Hydrogen BromideHCID 107995691-Acetyl-5-(acetoxymethyl)indazole

생성물 1

HCID 226614415-(Bromomethyl)-1H-indazole--hydrogen bromide (1/1)

실험 절차

A suspension of 1-acetyl-5-(acetoxymethyl)indazole (12-3) (3.0 g, 13 mmol) in aqueous hydrobromic acid (15 mL, 226 mmol) was stirred at room temperature for 25 hours. The solid was collected on a Buchner funnel and dried under vacuum for 12 hours. The filtrate was stirred at room temperature for additional 24 hours and more solid was collected. After drying under vacuum, title compound was obtained as a yellow solid (12-4, 3.48 g, 92%) which was used in the next synthesis step without further purification. 1H NMR (CDCl3) δ 4.88 (s, 2H), 7.43 (d, 1H, J=8.8), 7.56 (d, 1H, J=8.8 Hz), 7.87 (s, 1H), 8.10 (s, 1H).

후처리

  1. customThe solid was collected on a Buchner funnel
  2. customdried under vacuum for 12 hours
  3. stirringThe filtrate was stirred at room temperature for additional 24 hours
  4. custommore solid was collected
  5. customAfter drying under vacuum

출처 및 근거

ORD 기록
ord-a45ed7d998c04b23a6b0ccbd75ec0cee
출처 데이터셋
uspto-grants-2003_01
특허 번호
US06506760B1

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