Acetic Acid → Phenol, 2-fluoro-, acetate

HRID 1634731노트

반응식

HRID 1634731 반응식
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[OH:8].[C:9](O)(=[O:11])[CH3:10]>S(Cl)(Cl)=O>[C:9]([O:8][C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[F:1])(=[O:11])[CH3:10]

참가 물질

4

반응물 2

HCID 176Acetic AcidHCID 97072-Fluorophenol

생성물 1

HCID 141495Phenol, 2-fluoro-, acetate

시약·촉매·용매 1

HCID 24386Thionyl Chloride용매

반응 조건

온도
150 °C

실험 절차

2-Fluorophenol (99.4 g, 886.7 mmol) was stirred in thionyl chloride (71.2 mL) and acetic acid (51 mL) added. After the initial reaction had subsided the mixture was heated to reflux for 4 hours. The solution was then heated at 150° C. overnight. The resulting dark solution was distilled under reduced pressure at an oil bath temperature of 190° C. to give the title compound as a pale yellow oil (120.9 g, 784.4 mmol).

후처리

  1. customAfter the initial reaction
  2. temperaturewas heated
  3. temperatureto reflux for 4 hours
  4. distillationThe resulting dark solution was distilled under reduced pressure at an oil bath temperature of 190° C.

출처 및 근거

ORD 기록
ord-b567c8675b3744318ba9586de73a7f70
출처 데이터셋
uspto-grants-2003_01
특허 번호
US06506901B2

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