Sodium Hydroxide → (1-Propylpiperidin-4-yl)methanamine
반응식
[CH2:1]([N:4]1[CH2:9][CH2:8][CH:7]([C:10]([NH2:12])=O)[CH2:6][CH2:5]1)[CH2:2][CH3:3].[H-].[H-].[H-].[H-].[Li+].[Al+3].[OH-].[Na+].[O-]S([O-])(=O)=O.[Na+].[Na+]>C1COCC1.O>[NH2:12][CH2:10][CH:7]1[CH2:8][CH2:9][N:4]([CH2:1][CH2:2][CH3:3])[CH2:5][CH2:6]1참가 물질
7
실험 절차
A mixture of 1-propylpiperidine-4-carboxamide (1.2 g, 7.06 mmol) in 50 mL THF was treated in one portion with LAH (0.98 g, 14.2 mmol). The mixture was heated at reflux for 2 hours. On cooling the excess LAH was decomposed by the stepwise addition of H2O, 1N NaOH, H2O and Na2SO4 (v/v/v/w-1;1;3;12.5 based on 1 gram of LAH). After stirring for 10 min the solids were filtered and washed with EtOAc. The solvent was removed (rotovap) to give 0.9 g of title compound as a yellow oil.
후처리
- temperatureThe mixture was heated
- temperatureat reflux for 2 hours
- filtrationwere filtered
- washwashed with EtOAc
- customThe solvent was removed (rotovap)
출처 및 근거
- ORD 기록
- ord-13d8690dc7584548a6fb2594a052e01e
- 출처 데이터셋
- uspto-grants-2003_01
- 특허 번호
- US06506901B2
반응 노트
불러오는 중…
