Ammonium formate → HCID 70001232, 화합물

HRID 1634795노트

반응식

HRID 1634795 반응식
C([O:3][C:4](=[O:41])[C:5]1[CH:10]=[CH:9][C:8]([NH:11][C:12]([N:14]2[CH2:19][CH2:18][CH:17]([CH2:20][NH:21][CH2:22][C@H:23]([OH:40])[CH2:24][O:25][C:26]3[CH:31]=[CH:30][C:29]([O:32][CH2:33][C:34]4[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=4)=[CH:28][CH:27]=3)[CH2:16][CH2:15]2)=[O:13])=[CH:7][CH:6]=1)C.C([O-])=O.[NH4+]>CO.[Pd]>[OH:40][C@H:23]([CH2:24][O:25][C:26]1[CH:31]=[CH:30][C:29]([O:32][CH2:33][C:34]2[CH:35]=[CH:36][CH:37]=[CH:38][CH:39]=2)=[CH:28][CH:27]=1)[CH2:22][NH:21][CH2:20][CH:17]1[CH2:16][CH2:15][N:14]([C:12]([NH:11][C:8]2[CH:9]=[CH:10][C:5]([C:4]([OH:41])=[O:3])=[CH:6][CH:7]=2)=[O:13])[CH2:19][CH2:18]1

참가 물질

5

반응물 2

HCID 2723923Ammonium formateHCID 69999017HCID 69999017, 화합물

생성물 1

HCID 70001232HCID 70001232, 화합물수율 26.6%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

A mixture of 4-[(4-{[(2S)-2-hydroxy-3-(4-benzyloxy-phenoxy)-propylamino]-methyl}-piperidine-1-carbonyl)-amino]-benzoic acid ethyl ester (0.11 g, 0.43 mmol) and ammonium formate (0.063 g, 1 mmol) in 5 mL of methanol over 0.110 g of 10% palladium on carbon was stirred at ambient temperature overnight. The catalyst was filtered (solka floc) and the filtrate concentrated in vacuo. Trituration of the crude solid foam with Et2O provided 0.061 g of the title compound as a white solid.

후처리

  1. filtrationThe catalyst was filtered (solka floc)
  2. concentrationthe filtrate concentrated in vacuo

출처 및 근거

ORD 기록
ord-d3a51b463ce64ed181a51d0847bfb172
출처 데이터셋
uspto-grants-2003_01
특허 번호
US06506901B2

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