2,6-Difluorobenzoic acid → Benzamide, 2,6-difluoro-N-methyl-

HRID 1634808노트

반응식

[F:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]([F:11])[C:3]=1[C:4](O)=[O:5].[C:12](N1C=CN=C1)([N:14]1C=CN=C1)=O.Cl.CN.C(N(C(C)C)CC)(C)C>>[F:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]([F:11])[C:3]=1[C:4]([NH:14][CH3:12])=[O:5]

참가 물질

반응물 4

HCID 97962,6-Difluorobenzoic acid

HCID 682631,1'-Carbonyldiimidazole

HCID 81531Diisopropylethylamine

HCID 6364545Methylamine hydrochloride

생성물 1

HCID 4106176Benzamide, 2,6-difluoro-N-methyl-

실험 절차

The title compound was prepared from 2,6-difluorobenzoic acid (10 g, 63.2 mmol), carbonyldiimidazole (10.26 g, 63.5 mmol), methylamine hydrochloride (4.27 g, 63.25 mmol) and diisopropylethyl amine according to the procedure used for example 84 (Step A) to give near quantitative yield of the title compound.

출처 및 근거

ORD 기록: ord-87903239bff844dfb6b9479969497e88
출처 데이터셋: uspto-grants-2003_01
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06506901B2

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