Potassium Carbonate → HCID 69529373, 화합물

HRID 1634895노트

반응식

HRID 1634895 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:13]2[CH:18]=[C:17]([CH:19]=O)[CH:16]=[CH:15][N:14]=2)[CH:6]=[C:7]([O:11][CH3:12])[C:8]=1[O:9][CH3:10].C(OP([CH2:29][C:30]([O:32][CH2:33][CH3:34])=[O:31])(OCC)=O)C.C(=O)([O-])[O-].[K+].[K+]>C(O)(C)(C)C>[CH3:12][O:11][C:7]1[CH:6]=[C:5]([C:13]2[CH:18]=[C:17]([CH:19]=[CH:29][C:30]([O:32][CH2:33][CH3:34])=[O:31])[CH:16]=[CH:15][N:14]=2)[CH:4]=[C:3]([O:2][CH3:1])[C:8]=1[O:9][CH3:10]

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 13345Triethyl phosphonoacetateHCID 186750102-(3,4,5-Trimethoxyphenyl)pyridine-4-carboaldehyde

생성물 1

HCID 69529373HCID 69529373, 화합물

시약·촉매·용매 1

HCID 6386tert-Butanol용매

실험 절차

2-(3,4,5-Trimethoxyphenyl)pyridine-4-carboaldehyde (507 mg) and ethyl diethylphosphonoacetate (570 μL) were dissolved in tert-butanol (16 mL), and to the solution potassium carbonate (438 mg) was added. The mixture was stirred for 3 hours under reflux and concentrated under reduced pressure. The residue was dissolved in chloroform, and the solution was washed with saturated brine, dried over anhydrous magnesium sulfate and then concentrated under reduced pressure. The residue was purified by column chromatography on silica gel (hexane:ethyl acetate=1:1) to obtain the title compound.

후처리

  1. temperatureunder reflux
  2. concentrationconcentrated under reduced pressure
  3. dissolutionThe residue was dissolved in chloroform
  4. washthe solution was washed with saturated brine
  5. dry with materialdried over anhydrous magnesium sulfate
  6. concentrationconcentrated under reduced pressure
  7. customThe residue was purified by column chromatography on silica gel (hexane:ethyl acetate=1:1)

출처 및 근거

ORD 기록
ord-c634ae911fff4c32b5ded475a6b1c7d9
출처 데이터셋
uspto-grants-2003_01
특허 번호
US06509329B1

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