Water → 2-Hydroxy-3-(N,N-dibutylcarbamoylmethoxy)-3,3-diphenylpropionic acid

HRID 1635079노트

반응식

HRID 1635079 반응식
[OH:1][CH:2]([C:7]([O:20][CH2:21][C:22](=[O:32])[N:23]([CH2:28][CH2:29][CH2:30][CH3:31])[CH2:24][CH2:25][CH2:26][CH3:27])([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:3]([O:5]C)=[O:4].[OH-].[Na+].O>O1CCOCC1>[OH:1][CH:2]([C:7]([O:20][CH2:21][C:22](=[O:32])[N:23]([CH2:28][CH2:29][CH2:30][CH3:31])[CH2:24][CH2:25][CH2:26][CH3:27])([C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:3]([OH:5])=[O:4]

참가 물질

5

반응물 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 18675624methyl 2-hydroxy-3-(N,N-dibutylcarbamoylmethoxy)-3,3-diphenylpropionate

생성물 1

HCID 154275402-Hydroxy-3-(N,N-dibutylcarbamoylmethoxy)-3,3-diphenylpropionic acid수율 80%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

1.42 g of methyl 2-hydroxy-3-(N,N-dibutylcarbamoylmethoxy)-3,3-diphenylpropionate were dissolved in 10 ml of dioxane and 4.8 ml of 1N sodium hydroxide solution and stirred at room temperature for 3 hours. Water was then added to the mixture, and the aqueous phase was extracted with ether. The aqueous phase was acidified with hydrochloric acid and extracted with ethyl acetate, and the organic phase was dried over magnesium sulfate. After removal of the solvent by distillation, 1.1 g of oil were isolated and were immediately employed further.

후처리

  1. extractionthe aqueous phase was extracted with ether
  2. extractionextracted with ethyl acetate
  3. dry with materialthe organic phase was dried over magnesium sulfate
  4. customAfter removal of the solvent
  5. distillationby distillation

출처 및 근거

ORD 기록
ord-8a9e66e93f4b4cc993971a02d9a70cb8
출처 데이터셋
uspto-grants-2003_01
특허 번호
US06509341B1

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