Acetic Acid → 8-(3-Aminopiperidinyl)-1-Ethyl-9-Methoxy-4-Oxo-4H-Quinolizine-3-Carboxylic Acid

HRID 1635096노트

반응식

HRID 1635096 반응식
[NH2:1][CH:2]1[CH2:7][CH2:6][CH2:5][N:4]([C:8]2[CH:9]=[CH:10][N:11]3[C:16]([C:17]=2[O:18][CH3:19])=[C:15]([CH2:20][CH3:21])[CH:14]=[C:13]([C:22]([O:24]CC)=[O:23])[C:12]3=[O:27])[CH2:3]1.[OH-].[Li+].C(O)(=O)C>O.C1COCC1>[NH2:1][CH:2]1[CH2:7][CH2:6][CH2:5][N:4]([C:8]2[CH:9]=[CH:10][N:11]3[C:16]([C:17]=2[O:18][CH3:19])=[C:15]([CH2:20][CH3:21])[CH:14]=[C:13]([C:22]([OH:24])=[O:23])[C:12]3=[O:27])[CH2:3]1

참가 물질

6

반응물 3

HCID 176Acetic AcidHCID 3939Lithium HydroxideHCID 865895428-(3-Aminopiperidinyl)-1-Ethyl-9-Methoxy-4-Oxo-4H-Quinolizine-3-Carboxylic Acid, Ethyl Ester

생성물 1

HCID 186758698-(3-Aminopiperidinyl)-1-Ethyl-9-Methoxy-4-Oxo-4H-Quinolizine-3-Carboxylic Acid

시약·촉매·용매 2

HCID 962Water용매HCID 8028Tetrahydrofuran용매

반응 조건

온도
60 °C

실험 절차

8-(3-aminopiperidinyl)-1-ethyl-9-methoxy-4-oxo-4H-quinolizine-3-carboxylic acid, ethyl ester (0.028 g) is dissolved in 9 ml of a 2/1 mixture of water and THF and lithium hydroxide (0.035 g) is added. The resulting solution is stirred at 60° C. for 4 days and the solution adjusted to pH 7.2 by addition of acetic acid. The title compound is collected by filtration of the precipitate.

후처리

  1. additionis added
  2. filtrationThe title compound is collected by filtration of the precipitate

출처 및 근거

ORD 기록
ord-60347c174eb545f8afd1c725a5fbb70e
출처 데이터셋
uspto-grants-2003_01
특허 번호
US06509349B1

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