(2-Nitro-4-pyridin-2-yl-phenyl)-carbamic acid tert.-butyl ester → (2-Amino-4-pyridin-2-yl-phenyl)-carbamic acid tert.-butyl ester

HRID 1635192노트

반응식

HRID 1635192 반응식
[C:1]([O:5][C:6](=[O:23])[NH:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][N:15]=2)=[CH:10][C:9]=1[N+:20]([O-])=O)([CH3:4])([CH3:3])[CH3:2]>[Ni]>[C:1]([O:5][C:6](=[O:23])[NH:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][N:15]=2)=[CH:10][C:9]=1[NH2:20])([CH3:4])([CH3:2])[CH3:3]

참가 물질

3

반응물 1

HCID 69592830(2-Nitro-4-pyridin-2-yl-phenyl)-carbamic acid tert.-butyl ester

생성물 1

HCID 59737408(2-Amino-4-pyridin-2-yl-phenyl)-carbamic acid tert.-butyl ester

시약·촉매·용매 1

HCID 935Nickel촉매

실험 절차

Prepared from (2-nitro-4-pyridin-2-yl-phenyl)-carbamic acid tert.-butyl ester (Example C5) by catalytic hydrogenation with Raney-Ni according to the general procedure G (method a). Obtained as a light brown solid (339 mg).

출처 및 근거

ORD 기록
ord-8f3a85a3d8844b90b49c25ea472f58ea
출처 데이터셋
uspto-grants-2003_01
특허 번호
US06509328B1

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