Lithium Hydroxide → (2S)-1-(6-isobutyl-1,3-benzoxazol-2-yl)-2-piperidinecarboxylic acid
반응식
[CH2:1]([C:5]1[CH:23]=[CH:22][C:8]2[N:9]=[C:10]([N:12]3[CH2:17][CH2:16][CH2:15][CH2:14][C@H:13]3[C:18]([O:20]C)=[O:19])[O:11][C:7]=2[CH:6]=1)[CH:2]([CH3:4])[CH3:3].[OH-].[Li+]>>[CH2:1]([C:5]1[CH:23]=[CH:22][C:8]2[N:9]=[C:10]([N:12]3[CH2:17][CH2:16][CH2:15][CH2:14][C@H:13]3[C:18]([OH:20])=[O:19])[O:11][C:7]=2[CH:6]=1)[CH:2]([CH3:4])[CH3:3]참가 물질
3
실험 절차
The title compound was prepared by a similar method to Preparation 3 from methyl (2S)-1-(6-isobutyl-1,3-benzoxazol-2-yl)-2-piperidinecarboxylate [see Preparation 41] and 1N aqueous lithium hydroxide solution, to afford (2S)-1-(6-isobutyl-1,3-benzoxazol-2-yl)-2-piperidinecarboxylic acid as a foam.
출처 및 근거
- ORD 기록
- ord-3e0bddbc495c445aaffaf59ad6fe85f8
- 출처 데이터셋
- uspto-grants-2003_01
- 특허 번호
- US06509464B1
반응 노트
불러오는 중…