Ethylenediamine → HCID 18783142, 화합물

HRID 1636456노트

반응식

HRID 1636456 반응식
[CH3:1][C:2]1([CH3:11])[CH2:7][C:6]([CH3:9])([CH3:8])[CH2:5][C:4](=O)[CH2:3]1.C(N)CN.[N+:16]([CH3:19])([O-:18])=[O:17]>>[N+:16]([CH2:19][C:4]1[CH2:3][C:2]([CH3:11])([CH3:1])[CH2:7][C:6]([CH3:9])([CH3:8])[CH:5]=1)([O-:18])=[O:17]

참가 물질

4

반응물 3

HCID 3301EthylenediamineHCID 6375NitromethaneHCID 843993,3,5,5-Tetramethylcyclohexanone

생성물 1

HCID 18783142HCID 18783142, 화합물수율 61%

실험 절차

A solution of 3,3,5,5-tetramethylcyclohexanone (2-13) (1.54 g, 10 mmol) and ethylenediamine (60 mg) in nitromethane (45 ml) was refluxed in argon atmosphere for 25 h. Excess of nitromethane was then removed in vacuo and the residue was purified by flash chromatography on silica gel, eluting with hexane--ethyl acetate (6:1). 1.2 g (61%) of 6 was obtained as an oil.

후처리

  1. customExcess of nitromethane was then removed in vacuo
  2. customthe residue was purified by flash chromatography on silica gel
  3. washeluting with hexane--ethyl acetate (6:1)

출처 및 근거

ORD 기록
ord-65643282abb34c6b90532121dd8edec0
출처 데이터셋
uspto-grants-2000_03
특허 번호
US06034134

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