HCID 18434236, 화합물 → HCID 18434233, 화합물

HRID 1636734노트

반응식

HRID 1636734 반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:10]2[CH:15]=[C:14]([F:16])[C:13]([O:17]C)=[CH:12][C:11]=2[F:19])=[O:9])=[CH:4][CH:3]=1>C(O)(=O)C.Br>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]([C:10]2[CH:15]=[C:14]([F:16])[C:13]([OH:17])=[CH:12][C:11]=2[F:19])=[O:9])=[CH:6][CH:7]=1

참가 물질

4

반응물 1

HCID 18434236HCID 18434236, 화합물

생성물 1

HCID 18434233HCID 18434233, 화합물수율 94.9%

시약·촉매·용매 2

HCID 176Acetic Acid용매HCID 260Hydrogen Bromide용매

실험 절차

A solution of 22.9 g of (4-bromo-phenyl)-(2,5-difluoro-4-methoxy-phenyl)-methanone in 140 ml of acetic acid and 100 ml of 62% aqueous HBr solution is boiled under reflux for 13 hrs., subsequently evaporated, re-evaporated with toluene and taken up in ethyl acetate. The inorganic phase is washed with saturated sodium hydrogen carbonate solution and 10% sodium chloride solution and dried. After crystallization from methylene chloride/ether/pentane there are obtained 20.8 g of (4-bromo-phenyl)-(2,5-difluoro-4-hydroxy-phenyl)-methanone.

후처리

  1. temperatureunder reflux for 13 hrs
  2. custom, subsequently evaporated
  3. customre-evaporated with toluene
  4. washThe inorganic phase is washed with saturated sodium hydrogen carbonate solution and 10% sodium chloride solution
  5. customdried
  6. customAfter crystallization from methylene chloride/ether/pentane there

출처 및 근거

ORD 기록
ord-d97fae9e487d4aab9cb5de446f28b24d
출처 데이터셋
uspto-grants-2000_03
특허 번호
US06034275

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