Hydrochloric Acid → 5-Amino-2-phenyl-1,3,4,5-tetrahydrobenz[cd]indole hydrochloride

HRID 1637282노트

반응식

HRID 1637282 반응식
[NH2:1][CH:2]1[C:12]2[C:13]3[C:5](=[C:6]([C:14]4[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=4)[NH:7][C:8]=3[CH:9]=[CH:10][CH:11]=2)[CH2:4][CH2:3]1.[ClH:20]>C(O)C>[ClH:20].[NH2:1][CH:2]1[C:12]2[C:13]3[C:5](=[C:6]([C:14]4[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=4)[NH:7][C:8]=3[CH:9]=[CH:10][CH:11]=2)[CH2:4][CH2:3]1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 101988185-Amino-2-phenyl-1,3,4,5-tetrahydrobenz[cd]indole

생성물 1

HCID 193483565-Amino-2-phenyl-1,3,4,5-tetrahydrobenz[cd]indole hydrochloride수율 76%

시약·촉매·용매 1

HCID 702Ethanol용매2회

실험 절차

A portion (1.0 g) of the compound obtained in Example 81 was suspended in ethanol (10 ml) and to the suspension was added a solution (2.5 ml) of 20% hydrochloric acid in ethanol. The mixture was stirred for 10 minutes at room temperature. The reaction mixture was concentrated under reduced pressure. The crystals obtained were washed with ether and ether/methanol to yield 0.87 g (76%) of the titled compound as pale brown crystals.

후처리

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. customThe crystals obtained
  3. washwere washed with ether and ether/methanol

출처 및 근거

ORD 기록
ord-d6fba87e077448f9ad96bfde303fbda8
출처 데이터셋
uspto-grants-2000_03
특허 번호
US06040331

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