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Triethylamine hydrochloride → HCID 178440084, 화합물

HRID 1637365
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HRID 1637365 반응식
[C:1]([C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]1[CH:14]=[CH:13][C:12]([CH2:15][N:16]2[C:20]([C:21]([OH:23])=[O:22])=[C:19]([C:24]([OH:27])([CH3:26])[CH3:25])[N:18]=[C:17]2[CH2:28][CH2:29][CH3:30])=[CH:11][CH:10]=1)#[N:2].[N-:31]=[N+:32]=[N-:33].[Na+].Cl.C(N(CC)CC)C>C1(C)C=CC=CC=1>[OH:27][C:24]([C:19]1[N:18]=[C:17]([CH2:28][CH2:29][CH3:30])[N:16]([CH2:15][C:12]2[CH:11]=[CH:10][C:9]([C:4]3[CH:5]=[CH:6][CH:7]=[CH:8][C:3]=3[C:1]3[NH:33][N:32]=[N:31][N:2]=3)=[CH:14][CH:13]=2)[C:20]=1[C:21]([OH:23])=[O:22])([CH3:25])[CH3:26]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 11130Triethylamine hydrochlorideHCID 33557Sodium AzideHCID 193491411-(2'-Cyanobiphenyl-4-yl)methyl-4-(1-hydroxy-1-methylethyl)-2-propylimidazole-5-carboxylic acid

생성물 1

HCID 178440084HCID 178440084, 화합물수율 45%

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

Into the same device as used in Example 34 were placed 43.5 g (0.10 mole) of ethyl ester of 1-(2'-cyanobiphenyl-4-yl)methyl -4-(1-hydroxy-1-methylethyl)-2-propylimidazole-5-carboxylic acid, 8.5 g (0.13 mole) of sodium azide, 20.8 g (0.15 mole) of triethylamine hydrochloride and 206 ml of toluene. The mixture was reacted and treated in the same manner as in Example 34, giving 20.3 g (0.045 mole) of 4-(1-hydroxy-1-methylethyl) -2-propyl-1-{4-[2-(tetrazole -5-yl)phenyl]phenyl}methylimidazole-5-carboxylic acid (yield 45.0% based on ethyl ester of 1-(2'-cyanobiphenyl -4-yl)methyl-4-(1-hydroxy-1-methylethyl)-2-propylimidazole-5-carboxylic acid).

후처리

  1. customThe mixture was reacted
  2. additiontreated in the same manner as in Example 34

출처 및 근거

ORD 기록
ord-02eee94fa01e40da9bcd4e074d6bf32c
출처 데이터셋
uspto-grants-2000_03
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US06040454

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