Sodium borohydride → (E)-N,N-Diethyl-4-hydroxy-2-pentenamide
반응식
[CH2:1]([N:3]([CH2:11][CH3:12])[C:4](=[O:10])/[CH:5]=[CH:6]/[C:7](=[O:9])[CH3:8])[CH3:2].[BH4-].[Na+]>CO>[CH2:11]([N:3]([CH2:1][CH3:2])[C:4](=[O:10])/[CH:5]=[CH:6]/[CH:7]([OH:9])[CH3:8])[CH3:12]참가 물질
4
실험 절차
To (E)-N,N-diethyl-4-oxo-2-pentenamide (0.73 g, 4.31 mmol) in methanol (10 ml) cooled to 0° C. is added sodium borohydride (0.18 g, 4.75 mmol) under nitrogen stirred for minutes, quenched with excess water, and extracted with ethyl acetate (3×50 ml). The organic extracts are combined, washed with saline (50 ml), dried over sodium sulfate, concentrated in vacuo to give the title compound, NMR (CDCl3) 6.89, 6.42, 4.49, 3.41, 2.51, 1.33, 1.17.
후처리
- customquenched with excess water
- extractionextracted with ethyl acetate (3×50 ml)
- washwashed with saline (50 ml)
- dry with materialdried over sodium sulfate
- concentrationconcentrated in vacuo
출처 및 근거
- ORD 기록
- ord-128979d304664eeaa39e6bf4cacb299c
- 출처 데이터셋
- uspto-grants-2000_03
- 특허 번호
- US06043248
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