Ethanol → HCID 54527564, 화합물

HRID 1637933노트

반응식

HRID 1637933 반응식
[N+:1]([C:4]1[CH:5]=[C:6]([CH:15]=[CH:16][CH:17]=1)[CH:7]=[C:8]1[NH:12][C:11](=[O:13])[NH:10][C:9]1=[O:14])([O-])=O.NC1SC=C(C2C=CC(N)=CC=2)N=1.CCO>CN(C=O)C.[Ni]>[NH2:1][C:4]1[CH:5]=[C:6]([CH:15]=[CH:16][CH:17]=1)[CH:7]=[C:8]1[NH:12][C:11](=[O:13])[NH:10][C:9]1=[O:14]

참가 물질

6

반응물 3

HCID 702EthanolHCID 3778255-(3-nitrobenzylidene)imidazolidine-2,4-dioneHCID 6055642-Amino-4-(4-aminophenyl)thiazole

생성물 1

HCID 54527564HCID 54527564, 화합물

시약·촉매·용매 2

HCID 935Nickel촉매HCID 6228Dimethylformamide용매

실험 절차

2.3 g (10 mmol) of crude 3-nitro-benzylidene-hydantoin, melting point 280-284° C., (prepared as described in Example 6 in (a)) are hydrogenated in 60 ml of DMF and 40 ml EtOH on 2 g of Raney nickel for 36 hours at 20° C. and 3.5 bar. It is filtered over kieselguhr and the filtrate is evaporated down in vacuo. The evaporation residue is crystallised with ether.

후처리

  1. filtrationIt is filtered over kieselguhr
  2. customthe filtrate is evaporated down in vacuo
  3. customThe evaporation residue is crystallised with ether

출처 및 근거

ORD 기록
ord-868b03d787424b74b9f08e5b99c7e1e2
출처 데이터셋
uspto-grants-2000_03
특허 번호
US06043254

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