4-Nitrobenzaldehyde → 5-[(4-Aminophenyl)methylidene]-1,3-thiazolidine-2,4-dione

HRID 1637951

반응식

HRID 1637951 반응식
[N+:1]([C:4]1[CH:17]=[CH:16][C:7]([CH:8]=[C:9]2[S:13][C:12](=[O:14])[NH:11][C:10]2=[O:15])=[CH:6][CH:5]=1)([O-])=O.[N+](C1C=CC(C=O)=CC=1)([O-])=O.S1CC(=O)NC1=O.N1CCCCC1>C1(C)C=CC=CC=1.C(O)(=O)C.O>[NH2:1][C:4]1[CH:17]=[CH:16][C:7]([CH:8]=[C:9]2[S:13][C:12](=[O:14])[NH:11][C:10]2=[O:15])=[CH:6][CH:5]=1

참가 물질

8

반응물 4

HCID 5414-NitrobenzaldehydeHCID 5437ThiazolidinedioneHCID 8082PiperidineHCID 27682645-(4-Nitrobenzylidene)-1,3-thiazolidine-2,4-dione

생성물 1

HCID 541825435-[(4-Aminophenyl)methylidene]-1,3-thiazolidine-2,4-dione

시약·촉매·용매 3

HCID 176Acetic Acid용매HCID 962Water용매HCID 1140Toluene용매

실험 절차

Prepared by catalytic hydrogenation of 5-(4-nitro-benzylidene)-thiazolidin-2,4-dione [melting point: 265-270° C.; obtained by heating 4-nitro-benzaldehyde and 2 equivalents of thiazolidin-2,4-dione in the presence of piperidine in toluene using a water separator] in glacial acetic acid on palladium/charcoal (10%) (50° C., 3.5 bar, 0.5 hours).

후처리

  1. customobtained
  2. customon palladium/charcoal (10%) (50° C., 3.5 bar, 0.5 hours)

출처 및 근거

ORD 기록
ord-55b5b5f99ad647a0932ca3ac0aa578f8
출처 데이터셋
uspto-grants-2000_03
특허 번호
US06043254

연결된 노트

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