Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Nitrobenzaldehyde → 5-[(4-Aminophenyl)methylidene]-1,3-thiazolidine-2,4-dione
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Nitrobenzaldehyde | HCID 541 | — |
| 반응물 | Thiazolidinedione | HCID 5437 | — |
| 반응물 | Piperidine | HCID 8082 | — |
| 반응물 | 5-(4-Nitrobenzylidene)-1,3-thiazolidine-2,4-dione | HCID 2768264 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | 5-[(4-Aminophenyl)methylidene]-1,3-thiazolidine-2,4-dione | HCID 54182543 | — |
반응 단계
Prepared by catalytic hydrogenation of 5-(4-nitro-benzylidene)-thiazolidin-2,4-dione [melting point: 265-270° C.; obtained by heating 4-nitro-benzaldehyde and 2 equivalents of thiazolidin-2,4-dione in the presence of piperidine in toluene using a water separator] in glacial acetic acid on palladium/charcoal (10%) (50° C., 3.5 bar, 0.5 hours).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06043254 |
| 출처 데이터셋 | uspto-grants-2000_03 |
| ORD ID | ord-55b5b5f99ad647a0932ca3ac0aa578f8 |
| 출처 메모 | uspto-grants-2000_03 |