Hydrochloric Acid → HCID 178473964, 화합물

HRID 1637954

반응식

HRID 1637954 반응식
[C:1]([N:4]1[C:12]2[C:7](=[CH:8][C:9]([N+:13]([O-:15])=[O:14])=[CH:10][CH:11]=2)[CH2:6][C:5]1=[O:16])(=[O:3])[CH3:2].[F:17][C:18]([F:29])([F:28])[C:19]1[CH:27]=[CH:26][C:22]([C:23](O)=[O:24])=[CH:21][CH:20]=1.CN(C(ON1N=NC2C=CC=CC1=2)=[N+](C)C)C.[B-](F)(F)(F)F.C1C=CC2N(O)N=NC=2C=1.Cl>CN(C=O)C>[C:1]([N:4]1[C:12]2[C:7](=[CH:8][C:9]([N+:13]([O-:15])=[O:14])=[CH:10][CH:11]=2)[C:6](=[C:23]([OH:24])[C:22]2[CH:26]=[CH:27][C:19]([C:18]([F:17])([F:28])[F:29])=[CH:20][CH:21]=2)[C:5]1=[O:16])(=[O:3])[CH3:2]

참가 물질

7

반응물 5

HCID 313Hydrochloric AcidHCID 99664-(Trifluoromethyl)benzoic acidHCID 757711-HydroxybenzotriazoleHCID 2733207O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborateHCID 28393291-Acetyl-5-nitroindolin-2-one

생성물 1

HCID 178473964HCID 178473964, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

Prepared by reacting 1-acetyl-5-nitro-2-indolinone with one equivalent of 4-trifluoromethyl-benzoic acid in dry DMF in the presence of 1 equivalent each of TBTU and HOBT and 5 equivalents of Huinig's base (20° C., 4 hours), stirring into dilute hydrochloric acid, filtering the precipitate, dissolving the precipitate in EtOac, drying the organic phase and evaporation in vacuo and purifying the evaporation residue by column chromatography on silica gel with CH2Cl2 /MeOH (10:1) as eluant.

후처리

  1. customPrepared
  2. filtrationfiltering the precipitate
  3. dissolutiondissolving the precipitate in EtOac
  4. customdrying
  5. customthe organic phase and evaporation in vacuo
  6. custompurifying the evaporation residue by column chromatography on silica gel with CH2Cl2 /MeOH (10:1) as eluant

출처 및 근거

ORD 기록
ord-ced276462a764a7a8b4fce8abba231b5
출처 데이터셋
uspto-grants-2000_03
특허 번호
US06043254

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