1-Hydroxybenzotriazole → HCID 178473966, 화합물

HRID 1637963노트

반응식

HRID 1637963 반응식
[C:1]([N:4]1[C:12]2[C:7](=[CH:8][C:9]([N+:13]([O-:15])=[O:14])=[CH:10][CH:11]=2)[CH2:6][C:5]1=[O:16])(=[O:3])[CH3:2].[N:17]1([CH2:22][C:23]2[CH:31]=[CH:30][C:26]([C:27](O)=[O:28])=[CH:25][CH:24]=2)[CH:21]=[CH:20][N:19]=[CH:18]1.CN(C(ON1N=NC2C=CC=CC1=2)=[N+](C)C)C.[B-](F)(F)(F)F.C1C=CC2N(O)N=NC=2C=1.CCN(C(C)C)C(C)C>CN(C=O)C>[C:1]([N:4]1[C:12]2[C:7](=[CH:8][C:9]([N+:13]([O-:15])=[O:14])=[CH:10][CH:11]=2)[C:6](=[C:27]([OH:28])[C:26]2[CH:25]=[CH:24][C:23]([CH2:22][N:17]3[CH:21]=[CH:20][N:19]=[CH:18]3)=[CH:31][CH:30]=2)[C:5]1=[O:16])(=[O:3])[CH3:2]

참가 물질

7

반응물 5

HCID 757711-HydroxybenzotriazoleHCID 81531DiisopropylethylamineHCID 2733207O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborateHCID 28393291-Acetyl-5-nitroindolin-2-oneHCID 103304794-(1H-imidazol-1-ylmethyl)benzoic acid

생성물 1

HCID 178473966HCID 178473966, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

Prepared analogously to Example 10(a) from 1-acetyl-5-nitro-indolinone and 4-(imidazol-1-ylmethyl)benzoic acid in dry DMF in the presence of TBTU, HOBT and Hunig's base.

출처 및 근거

ORD 기록
ord-6e310311a75d49a88fed628e29737206
출처 데이터셋
uspto-grants-2000_03
특허 번호
US06043254

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