Methyl Isocyanate → HCID 14601660, 화합물

HRID 1638288노트

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HRID 1638288 반응식
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[S:9][C:8](=[O:10])[N:7]([CH2:11][C:12]([N:14]3[CH2:19][CH2:18][CH:17]([OH:20])[CH2:16][CH2:15]3)=[O:13])[C:6]=2[CH:21]=1.[CH3:22][N:23]=[C:24]=[O:25]>N1C=CC=CC=1>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[S:9][C:8](=[O:10])[N:7]([CH2:11][C:12]([N:14]3[CH2:15][CH2:16][CH:17]([O:20][C:24](=[O:25])[NH:23][CH3:22])[CH2:18][CH2:19]3)=[O:13])[C:6]=2[CH:21]=1

참가 물질

4

반응물 2

HCID 12228Methyl IsocyanateHCID 3082453Hpr 611

생성물 1

HCID 14601660HCID 14601660, 화합물수율 71.8%

시약·촉매·용매 1

HCID 1049Pyridine용매

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온도
30 °C

실험 절차

5-Chloro-3-(4-hydroxypiperidinocarbonylmethyl)benzothiazolin-2-one (3.2 g) was dissolved in dry pyridine (15 ml) and the solution was cooled. After methyl isocyanate (0.9 g) was dropwise added to the solution, the resultant was stirred for 15 hours at 30° C. Pyridine was evaporated off under vacuum from the reaction mixture and the residue was recrystallized from methanol to yield the title compound as colorless crystals (2.7 g). mp 202°-203° C.

후처리

  1. temperaturethe solution was cooled
  2. customPyridine was evaporated off under vacuum from the reaction mixture
  3. customthe residue was recrystallized from methanol

출처 및 근거

ORD 기록
ord-971f1681d3e74e3b9c571b190f6cc604
출처 데이터셋
uspto-grants-1989_11
특허 번호
US04879301

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