Hydrochloric Acid → 2-(3-Hydroxy-2-pyridyl)-4-thiazolecarboxylic acid

HRID 1638315노트

반응식

HRID 1638315 반응식
[OH:1][C:2]1[C:3]([C:8]2[S:9][CH:10]=[C:11]([C:13]([O:15]CC)=[O:14])[N:12]=2)=[N:4][CH:5]=[CH:6][CH:7]=1.[OH-].[K+].Cl>C(O)C.O>[OH:1][C:2]1[C:3]([C:8]2[S:9][CH:10]=[C:11]([C:13]([OH:15])=[O:14])[N:12]=2)=[N:4][CH:5]=[CH:6][CH:7]=1

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 135967484Ethyl 2-(3-hydroxy-2-pyridyl)-4-thiazolecarboxylate

생성물 1

HCID 1362052682-(3-Hydroxy-2-pyridyl)-4-thiazolecarboxylic acid수율 92.4%

시약·촉매·용매 2

HCID 702Ethanol용매HCID 962Water용매

실험 절차

To a solution of ethyl 2-(3-hydroxy-2-pyridyl)-4-thiazolecarboxylate (350 mg) dissolved in ethanol (7 ml) at 80° C. was added a solution of potassium hydroxide (436 mg) in water (5.5 ml) and the mixture was allowed to react at the same condition for 30 minutes. Then the reaction mixture was nuetralized with 1N--HCl under ice-cooling. The resulting solids were sucked off and dried to give yellowish crystals of 2-(3-hydroxy-2-pyridyl)-4-thiazolecarboxylic acid (287 mg, 92%), m.p. above 300° C.

후처리

  1. customto react at the same condition for 30 minutes
  2. customdried

출처 및 근거

ORD 기록
ord-fa714af956674eee80af1b01bc30c5d6
출처 데이터셋
uspto-grants-1989_11
특허 번호
US04879295

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