Ethyl Acetate → 1-(3-Chlorophenyl)-3-(dimethylaminomethylene)-2(1H,3H)-indolone

HRID 1638450노트

반응식

HRID 1638450 반응식
CO[CH:3](OC)[N:4]([CH3:6])[CH3:5].COC(OC)(N(C)C)C.C(OCC)(=O)C.[Cl:24][C:25]1[CH:26]=[C:27]([N:31]2[C:39]3[C:34](=[CH:35][CH:36]=[CH:37][CH:38]=3)[CH2:33][C:32]2=[O:40])[CH:28]=[CH:29][CH:30]=1>C(Cl)Cl>[Cl:24][C:25]1[CH:26]=[C:27]([N:31]2[C:39]3[C:34](=[CH:35][CH:36]=[CH:37][CH:38]=3)[C:33](=[CH:3][N:4]([CH3:6])[CH3:5])[C:32]2=[O:40])[CH:28]=[CH:29][CH:30]=1

참가 물질

6

반응물 4

HCID 8857Ethyl AcetateHCID 78373Dimethylformamide dimethyl acetalHCID 878351,1-Dimethoxyethyl(dimethyl)amineHCID 112995301-(3-Chlorophenyl)-indolin-2-one

생성물 1

HCID 537196081-(3-Chlorophenyl)-3-(dimethylaminomethylene)-2(1H,3H)-indolone

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

By the procedure of Example Al, but substituting an equivalent of dimethylformamide dimethylacetal for the dimethylacetamide dimethylacetal, using first methylene chloride and then 7.5% ethyl acetate in methylene chloride in chromatography and recrystallization from ether-pentane, 1-(3-chlorophenyl)-2(1H,3H)-indolone (10 g, 0.041 mole) was converted to title product, 3.73 g, m.p. 116°-118°.

출처 및 근거

ORD 기록
ord-6678a8db142042e09b34d011524e4999
출처 데이터셋
uspto-grants-1989_11
특허 번호
US04879391

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