Sodium Hydroxide → 3,4-Dihydro-6-(phenylmethoxy)-2-naphthalenecarboxylic acid

HRID 1638789노트

반응식

HRID 1638789 반응식
[CH2:1]([O:8][C:9]1[CH:10]=[C:11]2[C:16](=[CH:17][CH:18]=1)[CH:15](O)[CH:14]([C:20]([OH:22])=[O:21])[CH2:13][CH2:12]2)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[Na+]>CO>[CH2:1]([O:8][C:9]1[CH:10]=[C:11]2[C:16]([CH:15]=[C:14]([C:20]([OH:22])=[O:21])[CH2:13][CH2:12]2)=[CH:17][CH:18]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 19841196HCID 19841196, 화합물

생성물 1

HCID 146761973,4-Dihydro-6-(phenylmethoxy)-2-naphthalenecarboxylic acid수율 79.8%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Methyl ester of 6-benzyloxy-1-hydroxy-1,2,3,4-tetrahydro-2-naphthoic acid (0.6 g) is dissolved in methanol (50 ml). To the solution is added an aqueous solution (10 ml) of sodium hydroxide (2 g), and the mixture is left standing for 30 minutes at room temperature. The resultant is concentrated under reduced pressure. The concentrate is diluted with water (50 ml). The precipitating crystals are collected by filtration. This product is dissolved in a mixture of dioxane (50 ml) and concentrated hydrochloric acid (2 ml). The mixture is left standing for 5 minutes at 80° C. and then for 30 minutes at room temperature. The resultant is concentrated under reduced pressure. Water (50 ml) is added to the concentrate. The precipitating crystals are collected by filtration to give 7-benzyloxy-1,2-dihydro-3-naphthoic acid (0.45 g) as colorless crystals, followed by recrystallization from a mixture of methanol and acetone to afford colorless needles, m.p. 202°-205° C.

후처리

  1. waitthe mixture is left
  2. concentrationThe resultant is concentrated under reduced pressure
  3. additionThe concentrate is diluted with water (50 ml)
  4. filtrationThe precipitating crystals are collected by filtration
  5. dissolutionThis product is dissolved in a mixture of dioxane (50 ml) and concentrated hydrochloric acid (2 ml)
  6. waitThe mixture is left
  7. waitstanding for 5 minutes at 80° C.
  8. waitfor 30 minutes at room temperature
  9. concentrationThe resultant is concentrated under reduced pressure
  10. additionWater (50 ml) is added to the concentrate
  11. filtrationThe precipitating crystals are collected by filtration

출처 및 근거

ORD 기록
ord-c2d425b448184586907ebbbe175e633e
출처 데이터셋
uspto-grants-1989_11
특허 번호
US04880809

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