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Benzyl Bromide → 1-Benzyl-5-(octyloxy)pyrrolidin-2-one

HRID 1639042
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HRID 1639042 반응식
[CH2:1]([O:9][CH:10]1[NH:14][C:13](=[O:15])[CH2:12][CH2:11]1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8].[OH-].[K+].[CH2:18](Br)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>[Br-].C([N+](CCCC)(CCCC)CCCC)CCC.O1CCCC1>[CH2:18]([N:14]1[CH:10]([O:9][CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8])[CH2:11][CH2:12][C:13]1=[O:15])[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 3

HCID 7498Benzyl BromideHCID 14797Potassium HydroxideHCID 15696565HCID 15696565, 화합물

생성물 1

HCID 30779651-Benzyl-5-(octyloxy)pyrrolidin-2-one수율 70.5%

시약·촉매·용매 2

HCID 74236Tetrabutylammonium Bromide촉매HCID 8028Tetrahydrofuran
용매
2회

실험 절차

To a mixture of 2 g of 5-n-octyloxy-pyrrolidin-2-one, 0.65 g of potassium hydroxide at 85% and 0.2 g of tetra-n-butylammonium bromide in 40 cm3 of tetrahydrofuran, there is added a solution of 1.6 g of benzyl bromide in 5 cm3 of tetrahydrofuran, without exceeding 30° C. After agitating for 2 hours at ambient temperature, filtering and evaporating to dryness, the residue is chromatographed on alumina, (eluent: ethyl acetate--cyclo-hexane, 1--1), and 2 g of the expected product is obtained.

후처리

  1. customwithout exceeding 30° C
  2. filtrationfiltering
  3. customevaporating to dryness
  4. customthe residue is chromatographed on alumina, (eluent: ethyl acetate--cyclo-hexane, 1--1),

출처 및 근거

ORD 기록
ord-94007ebbc3d94fb99e2ef904bdaa1e76
출처 데이터셋
uspto-grants-1989_11
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US04882350

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