Hydrochloric Acid → 5-(2-Aminomethylpropan-2-yl)-2-(4-methylphenyl)benzimidazole
반응식
C([NH:4][CH2:5][C:6]([C:9]1[CH:24]=[CH:23][C:12]2[N:13]=[C:14]([C:16]3[CH:21]=[CH:20][C:19]([CH3:22])=[CH:18][CH:17]=3)[NH:15][C:11]=2[CH:10]=1)([CH3:8])[CH3:7])(=O)C.Cl>C(O)C>[NH2:4][CH2:5][C:6]([C:9]1[CH:24]=[CH:23][C:12]2[N:13]=[C:14]([C:16]3[CH:17]=[CH:18][C:19]([CH3:22])=[CH:20][CH:21]=3)[NH:15][C:11]=2[CH:10]=1)([CH3:8])[CH3:7]참가 물질
4
실험 절차
1.45 g. of the compound prepared in Example 26 is boiled under reflux for 48 hours in 35 ml. ethanol and 35 ml. concentrated hydrochloric acid. The solvent is removed in a vacuum and the residue is dissolved in water and neutralised with 2N aqueous ammonia solution. The substance which precipitates out is filtered off with suction. There is obtained 1.1 g. of the title compound; m.p. 45°-48° C.