Triethylamine → 4-bromo-N-(4-bromo-2-fluorobenzyl)-2-nitrobenzamide

HRID 1639297

반응식

HRID 1639297 반응식
[Br:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][NH2:7])=[C:4]([F:10])[CH:3]=1.C(N(CC)CC)C.[Br:18][C:19]1[CH:27]=[CH:26][C:22]([C:23](Cl)=[O:24])=[C:21]([N+:28]([O-:30])=[O:29])[CH:20]=1>C(Cl)(Cl)Cl>[Br:18][C:19]1[CH:27]=[CH:26][C:22]([C:23]([NH:7][CH2:6][C:5]2[CH:8]=[CH:9][C:2]([Br:1])=[CH:3][C:4]=2[F:10])=[O:24])=[C:21]([N+:28]([O-:30])=[O:29])[CH:20]=1

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 3770848(4-Bromo-2-fluorophenyl)methanamineHCID 189198804-Bromo-2-nitrobenzoyl chloride

생성물 1

HCID 144589874-bromo-N-(4-bromo-2-fluorobenzyl)-2-nitrobenzamide수율 81.9%

시약·촉매·용매 1

HCID 6212Chloroform용매2회

실험 절차

To a solution of 4-bromo-2-fluorobenzylamine (2.3 g) and triethylamine (1.55 ml) in chloroform (40 ml) was added dropwise a solution of 4-bromo-2-nitrobenzoyl chloride (2.69 g) in chloroform (10 ml) at 0° C. with stirring and the mixture was stirred at the same temperature for 1 hour. The reaction mixture was washed in turn with diluted aqueous hydrochloric acid and water, and then dried. Evaporation of the solvent followed by recrystallization from diethyl ether gave 4-bromo-N-(4-bromo-2-fluorobenzyl)-2-nitrobenzamide (3.60 g).

후처리

  1. stirringthe mixture was stirred at the same temperature for 1 hour
  2. washThe reaction mixture was washed in turn with diluted aqueous hydrochloric acid and water
  3. customdried
  4. customEvaporation of the solvent
  5. customfollowed by recrystallization from diethyl ether

출처 및 근거

ORD 기록
ord-acb49f0dbaa5489e8e7915b30e3a5ec7
출처 데이터셋
uspto-grants-1989_11
특허 번호
US04883800

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