Sodium Hydroxide → 2-Cyano-2-cyclopropylacetic acid
반응식
[OH-].[Na+].C([O:5][C:6](=[O:13])[CH:7]([C:11]#[N:12])[CH:8]1[CH2:10][CH2:9]1)C>C1COCC1>[C:11]([CH:7]([CH:8]1[CH2:10][CH2:9]1)[C:6]([OH:13])=[O:5])#[N:12]참가 물질
4
반응 조건
- 온도
- 25 °C
실험 절차
IN NaOH (3.26 ml, 3.26 mmol) was added to a solution of cyano-cyclopropyl-acetic acid ethyl ester (0.5 g, 3.26 mmol) in THF (15 ml). After 4 hours stirring at 25° C., the reaction mixture was evaporated in vacuo, re-dissolved in water (20 ml) and neutralized by the addition of 1N HCl solution (3.26 ml). This mixture was then extracted with EtOAc (3×20 ml) and the combined, dried (Na2SO4) organics evaporated ill vacuo to give impure cyano-cyclopropyl-acetic acid as a clear oil. This material was used without any further purification in the preparation of Example 4B.
후처리
- customthe reaction mixture was evaporated in vacuo
- dissolutionre-dissolved in water (20 ml)
- additionneutralized by the addition of 1N HCl solution (3.26 ml)
- extractionThis mixture was then extracted with EtOAc (3×20 ml)
- dry with materialdried (Na2SO4) organics evaporated ill vacuo
출처 및 근거
- ORD 기록
- ord-f188a6c31bcd493c9b5d71c49ab18abf
- 출처 데이터셋
- uspto-grants-2012_02
- 특허 번호
- US08110573B2
반응 노트
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