Sodium Hydroxide → (2-Methylpyrazolo[1,5-a]pyridin-4-yl)methanol

HRID 1639743노트

반응식

HRID 1639743 반응식
[OH:1][CH2:2][C:3]1[C:4]2[N:5]([N:9]=[C:10]([CH3:17])[C:11]=2C(OCC)=O)[CH:6]=[CH:7][CH:8]=1.[OH-].[Na+]>S(=O)(=O)(O)O>[CH3:17][C:10]1[CH:11]=[C:4]2[C:3]([CH2:2][OH:1])=[CH:8][CH:7]=[CH:6][N:5]2[N:9]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 59334472Ethyl 4-(hydroxymethyl)-2-methylpyrazolo[1,5-a]pyridine-3-carboxylate

생성물 1

HCID 59334539(2-Methylpyrazolo[1,5-a]pyridin-4-yl)methanol수율 99%

시약·촉매·용매 1

HCID 1118Sulfuric Acid용매

반응 조건

온도
100 °C

실험 절차

A mixture of ethyl 4-(hydroxymethyl)-2-methylpyrazolo[1,5-a]pyridine-3-carboxylate (41.0 g, 0.180 mol) and 40% aqueous sulfuric acid solution (350 mL) was stirred at 100° C. for 2 hr. The reaction mixture was basified with 10% aqueous sodium hydroxide solution, and extracted with dichloromethane. The extract was dried over anhydrous sodium sulfate and the solvent was evaporated under reduced pressure to give the title compound (28.0 g, yield 99%).

후처리

  1. extractionextracted with dichloromethane
  2. dry with materialThe extract was dried over anhydrous sodium sulfate
  3. customthe solvent was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-34668994e19f439cace307091e02eaa3
출처 데이터셋
uspto-grants-2012_02
특허 번호
US08110585B2

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