Hydrazine hydrate (1:1) → cis-1-[2-(2-methyl-2H-indazol-4-yl)cyclopropyl]methanamine

HRID 1639768노트

반응식

HRID 1639768 반응식
[CH3:1][N:2]1[CH:10]=[C:9]2[C:4]([CH:5]=[CH:6][CH:7]=[C:8]2[C@H:11]2[CH2:13][C@H:12]2[CH2:14][N:15]2C(=O)C3C(=CC=CC=3)C2=O)=[N:3]1.O.NN>C(O)C>[CH3:1][N:2]1[CH:10]=[C:9]2[C:4]([CH:5]=[CH:6][CH:7]=[C:8]2[C@H:11]2[CH2:13][C@H:12]2[CH2:14][NH2:15])=[N:3]1

참가 물질

4

반응물 2

HCID 24654Hydrazine hydrate (1:1)HCID 66720712HCID 66720712, 화합물

생성물 1

HCID 66720689cis-1-[2-(2-methyl-2H-indazol-4-yl)cyclopropyl]methanamine

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A crudely purified product of cis-2-{[2-(2-methyl-2H-indazol-4-yl)cyclopropyl]methyl}-1H-isoindole-1,3(2H)-dione was dissolved in ethanol (6.5 mL), and hydrazine monohydrate (3 mL) was added. The mixture was heated under reflux for 20 min. The solvent was evaporated under reduced pressure. Saturated aqueous sodium hydrogen carbonate solution was added to the residue, and the mixture was extracted with ethyl acetate. The extract was dried over anhydrous sodium sulfate and the solvent was evaporated under reduced pressure to give the title compound as a crudely purified product.

후처리

  1. temperatureThe mixture was heated
  2. temperatureunder reflux for 20 min
  3. customThe solvent was evaporated under reduced pressure
  4. additionSaturated aqueous sodium hydrogen carbonate solution was added to the residue
  5. extractionthe mixture was extracted with ethyl acetate
  6. dry with materialThe extract was dried over anhydrous sodium sulfate
  7. customthe solvent was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-f66e6b321fc1401fad3f65b85370967c
출처 데이터셋
uspto-grants-2012_02
특허 번호
US08110585B2

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