Benzylamine → Benzyl-(2,2,2-trifluoro-ethyl)-amine

HRID 1640236

반응식

HRID 1640236 반응식
[F:1][C:2]([F:13])([F:12])[CH2:3]OS(C(F)(F)F)(=O)=O.[CH2:14]([NH2:21])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>C1(C)C(C)=CC=CC=1>[CH2:14]([NH:21][CH2:3][C:2]([F:13])([F:12])[F:1])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

참가 물질

4

반응물 2

HCID 7504BenzylamineHCID 803662,2,2-Trifluoroethyl trifluoromethanesulfonate

생성물 1

HCID 4962181Benzyl-(2,2,2-trifluoro-ethyl)-amine

시약·촉매·용매 1

HCID 7237O-Xylene용매

실험 절차

2.2 g (9.4 mmol) 2,2,2-trifluoroethyltrifluoromethanesulphonate were added to 2.0 g (18.7 mmol) benzylamine in 50 mL xylene and the reaction mixture was refluxed overnight. After cooling the precipitate formed was suction filtered, washed with DIPE and the filtrate was evaporated down using the rotary evaporator. The residue was purified by flash chromatography. The product fractions were combined and evaporated down i.vac.

후처리

  1. temperaturethe reaction mixture was refluxed overnight
  2. temperatureAfter cooling the precipitate
  3. customformed
  4. filtrationfiltered
  5. washwashed with DIPE
  6. customthe filtrate was evaporated down
  7. customthe rotary evaporator
  8. customThe residue was purified by flash chromatography
  9. customevaporated down i.vac

출처 및 근거

ORD 기록
ord-8a79d718fc0d408cab994cbe2103242d
출처 데이터셋
uspto-grants-2012_02
특허 번호
US08110575B2

연결된 노트

불러오는 중…