Diisopropylethylamine → 1-(6-(indoline-1-carbonyl)pyrimidin-4-yl)spiro[piperidine-4,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one

HRID 1640266노트

반응식

HRID 1640266 반응식
[NH:1]1[C:5]2=[N:6][CH:7]=[CH:8][CH:9]=[C:4]2[C:3]2([CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)[C:2]1=[O:15].Cl[C:17]1[N:22]=[CH:21][N:20]=[C:19]([C:23]([N:25]2[C:33]3[C:28](=[CH:29][CH:30]=[CH:31][CH:32]=3)[CH2:27][CH2:26]2)=[O:24])[CH:18]=1.CCN(C(C)C)C(C)C>CN(C=O)C>[N:25]1([C:23]([C:19]2[N:20]=[CH:21][N:22]=[C:17]([N:12]3[CH2:11][CH2:10][C:3]4([C:4]5[C:5](=[N:6][CH:7]=[CH:8][CH:9]=5)[NH:1][C:2]4=[O:15])[CH2:14][CH2:13]3)[CH:18]=2)=[O:24])[C:33]2[C:28](=[CH:29][CH:30]=[CH:31][CH:32]=2)[CH2:27][CH2:26]1

참가 물질

5

반응물 3

HCID 81531DiisopropylethylamineHCID 56651734Spiro[piperidine-4,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-oneHCID 58117518(6-Chloropyrimidin-4-yl)-(2,3-dihydroindol-1-yl)-methanone

생성물 1

HCID 426100731-(6-(indoline-1-carbonyl)pyrimidin-4-yl)spiro[piperidine-4,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

43 mg (0.21 mmol) spiro[piperidine-4,3′-pyrrolo[2,3-b]pyridin]-2′(1′H)-one were added to 50 mg (0.19 mmol) (6-chloro-pyrimidin-4-yl)-(2,3-dihydro-indol-1-yl)-methanone and 52 μL (0.58 mmol) DIPEA in 5 mL DMF. The reaction mixture was stirred for 2 h at RT. The reaction mixture was evaporated down using the rotary evaporator and the residue was mixed with 20 mL water and stirred for 30 min at RT. The product precipitated was suction filtered, stirred with diisopropylether and isopropanol, suction filtered and dried.

후처리

  1. customThe reaction mixture was evaporated down
  2. customthe rotary evaporator
  3. additionthe residue was mixed with 20 mL water
  4. stirringstirred for 30 min at RT
  5. customThe product precipitated
  6. filtrationfiltered
  7. stirringstirred with diisopropylether and isopropanol, suction
  8. filtrationfiltered
  9. customdried

출처 및 근거

ORD 기록
ord-0c73855477984bb493bcf676f4b1cebe
출처 데이터셋
uspto-grants-2012_02
특허 번호
US08110575B2

반응 노트

불러오는 중…