Dimethyl Sulfoxide → (S)-3-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-2-oxo-oxazolidine-5-carbaldehyde

온도

0 °C

A solution of oxalyl chloride (0.229 mL, 2.71 mmol) in DCM (5 mL) was cooled to −78° C. and DMSO (0.395 mL, 5.572 mmol) was added dropwise. The mixture was stirred for 10 min at that temperature and a suspension of (S)-3-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-5-hydroxymethyl-oxazolidin-2-one (400 mg, 1.59 mmol) in DCM (6 mL) was then added dropwise within 1 min. Stirring was continued for 20 min. TEA (0.665 mL, 4.78 mmol) was added and the mixture was stirred for 5 min, and then allowed to warm to 0° C. The mixture was filtered through Celite and concentrated with a bath temperature below 30° C. The residue was partitioned between water and EA and the org. layer was washed with brine, dried over Na2SO4 and concentrated with a bath temperature below 30° C. The highly unstable intermediate was used immediately in the next step.

1. additionwas then added dropwise within 1 min
2. stirringStirring
3. waitwas continued for 20 min
4. stirringthe mixture was stirred for 5 min
5. filtrationThe mixture was filtered through Celite
6. concentrationconcentrated with a bath temperature below 30° C
7. customThe residue was partitioned between water and EA
8. washlayer was washed with brine
9. dry with materialdried over Na2SO4
10. concentrationconcentrated with a bath temperature below 30° C

ORD 기록

ord-98ad07b8ad1a4051819ffc4a41c2b23c

출처 데이터셋

uspto-grants-2012_02

DOI

10.6084/m9.figshare.5104873.v1

특허 번호

US08114867B2