Ethylenediamine → HCID 68601740, 화합물

HRID 1640546노트

반응식

HRID 1640546 반응식
Cl[C:2]1[CH:3]=[CH:4][N:5]=[C:6]2[C:11]=1[N:10]=[C:9]([O:12][CH3:13])[CH:8]=[CH:7]2.[CH2:14]([NH2:17])[CH2:15][NH2:16]>C(Cl)Cl>[CH3:13][O:12][C:9]1[N:10]=[C:11]2[C:6](=[CH:7][CH:8]=1)[N:5]=[CH:4][CH:3]=[C:2]2[NH:16][CH2:15][CH2:14][NH2:17]

참가 물질

4

반응물 2

HCID 3301EthylenediamineHCID 222443958-Chloro-2-methoxy-1,5-naphthyridine

생성물 1

HCID 68601740HCID 68601740, 화합물수율 51%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

반응 조건

온도
100 °C

실험 절차

A mixture of 8-chloro-2-methoxy-[1,5]naphthyridine (commercial; 1.7 g, 8.80 mmol) and ethane-1,2-diamine (1.2 mL, 2 eq.) was heated slowly to 80° C. over 1 h and subsequently up to 100° C. for 2 h. After cooling to rt, the yellow solution was taken up in DCM and successively washed with sat. aq. NaHCO3. The org. layer was concentrated under reduced pressure to afford the title intermediate as a pale yellow oil (981 mg, 51% yield).

후처리

  1. temperatureAfter cooling to rt
  2. washsuccessively washed with sat. aq. NaHCO3
  3. concentrationlayer was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-806e442c4a434d4698c807bbab7c71bb
출처 데이터셋
uspto-grants-2012_02
특허 번호
US08114867B2

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