Potassium Hydroxide → 2-Fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)aniline

HRID 16407

반응식

HRID 16407 반응식
Cl[C:2]1[CH:7]=[CH:6][N:5]=[C:4]2[NH:8][CH:9]=[CH:10][C:3]=12.[F:11][C:12]1[CH:18]=[C:17]([OH:19])[CH:16]=[CH:15][C:13]=1[NH2:14].[OH-].[K+]>O>[F:11][C:12]1[CH:18]=[C:17]([O:19][C:2]2[CH:7]=[CH:6][N:5]=[C:4]3[NH:8][CH:9]=[CH:10][C:3]=23)[CH:16]=[CH:15][C:13]=1[NH2:14]

참가 물질

5

반응물 3

HCID 14797Potassium HydroxideHCID 27359194-Amino-3-fluorophenolHCID 113894934-Chloro-1H-pyrrolo[2,3-b]pyridine

생성물 1

HCID 179793512-Fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)aniline

시약·촉매·용매 1

HCID 962Water용매

실험 절차

100 mg (660 μmol) of 4-chloro-1H-pyrrolo[2,3-b]pyridine (from example XVIII), 166 mg (1.31 mmol) of 2-fluoro-4-hydroxyaniline and 73.5 mg (1.31 mmol) of powdered potassium hydroxide are heated at 260° C. for 8 hours. For work-up, the mixture is cooled to room temperature, diluted with water and extracted three times with ethyl acetate. The organic phase is dried over magnesium sulfate and concentrated using a rotary evaporator. The residue is purified by preparative HPLC.

후처리

  1. extractionextracted three times with ethyl acetate
  2. dry with materialThe organic phase is dried over magnesium sulfate
  3. concentrationconcentrated
  4. customa rotary evaporator
  5. customThe residue is purified by preparative HPLC

출처 및 근거

ORD 기록
ord-b6ddfe09432349159627580791e74162
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07737153B2

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