Sulfuric Acid → 1H-indazol-4-ol

HRID 16411

반응식

HRID 16411 반응식
[NH:1]1[C:9]2[C:4](=[C:5](N)[CH:6]=[CH:7][CH:8]=2)[CH:3]=[N:2]1.S(=O)(=O)(O)[OH:12].[OH-].[Na+]>>[NH:1]1[C:9]2[CH:8]=[CH:7][CH:6]=[C:5]([OH:12])[C:4]=2[CH:3]=[N:2]1

참가 물질

4

반응물 3

HCID 1118Sulfuric AcidHCID 14798Sodium HydroxideHCID 413085NoName_3327

생성물 1

HCID 1357424501H-indazol-4-ol

실험 절차

500 mg (375 mmol) of 1H-indazol-4-ylamine (prepared according to J. Chem. Soc. 1955, 2412, 2419) are stirred in 10% strength sulfuric acid at 180° C. in an autoclave at intrinsic pressure overnight. The reaction solution is cooled to room temperature and neutralized with 1N sodium hydroxide solution, and the salts are filtered off. The filtrate is concentrated to dryness.

후처리

  1. filtrationthe salts are filtered off
  2. concentrationThe filtrate is concentrated to dryness

출처 및 근거

ORD 기록
ord-3424705caf554a55a61da2572693309a
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07737153B2

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