Hydrochloric Acid → (1R,2S)-1-amino-2-methylindane hydrochloride

HRID 1641379노트

반응식

HRID 1641379 반응식
[ClH:1].[CH3:2][C@H:3]1[CH2:11][C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C@@H:4]1[NH:12]C(=O)COC>C(O)C.O>[ClH:1].[NH2:12][C@H:4]1[C:5]2[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=2)[CH2:11][C@@H:3]1[CH3:2]

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 66739634N-[(1R,2S)-2-methyl-1-indanyl]-2-methoxyacetamide

생성물 1

HCID 66739261(1R,2S)-1-amino-2-methylindane hydrochloride

시약·촉매·용매 2

HCID 702Ethanol용매HCID 962Water용매

실험 절차

Concentrated hydrochloric acid (8 ml) was added to a solution of N-[(1R,2S)-2-methyl-1-indanyl]-2-methoxyacetamide (5.9 g, 0.0269 mol) in ethanol and water, and the mixture heated for 12 hours at reflux. The solvent was evaporated and a small amount of ethyl acetate added. The undissolved solid was filtered off to give (1R,2S)-1-amino-2-methylindane hydrochloride (1.0 g) as a solid, chemical purity>95%.

후처리

  1. temperaturethe mixture heated for 12 hours
  2. temperatureat reflux
  3. customThe solvent was evaporated
  4. additiona small amount of ethyl acetate added
  5. filtrationThe undissolved solid was filtered off

출처 및 근거

ORD 기록
ord-a361b52d3240489d809eb2c9b5bb01f2
출처 데이터셋
uspto-grants-2012_02
특허 번호
US08114991B2

반응 노트

불러오는 중…