Hydrochloric Acid → (5-{4-[3-Amino-4-hydroxy-3-(hydroxymethyl)butyl]phenyl}-2-thienyl)(4-methylphenyl)ketone

HRID 1641573노트

반응식

HRID 1641573 반응식
CC1(C)[O:7][CH2:6][C:5]([NH:30]C(=O)C)([CH2:8][CH2:9][C:10]2[CH:15]=[CH:14][C:13]([C:16]3[S:17][C:18]([C:21](=[O:29])[C:22]4[CH:27]=[CH:26][C:25]([CH3:28])=[CH:24][CH:23]=4)=[CH:19][CH:20]=3)=[CH:12][CH:11]=2)[CH2:4][O:3]1.Cl>C(O)C>[NH2:30][C:5]([CH2:4][OH:3])([CH2:6][OH:7])[CH2:8][CH2:9][C:10]1[CH:15]=[CH:14][C:13]([C:16]2[S:17][C:18]([C:21]([C:22]3[CH:23]=[CH:24][C:25]([CH3:28])=[CH:26][CH:27]=3)=[O:29])=[CH:19][CH:20]=2)=[CH:12][CH:11]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 57624584N-[2,2-dimethyl-5-(2-{4-[5-(4-methylbenzoyl)-2-thienyl]phenyl}ethyl)-1,3-dioxan-5-yl]acetamide

생성물 1

HCID 57624612(5-{4-[3-Amino-4-hydroxy-3-(hydroxymethyl)butyl]phenyl}-2-thienyl)(4-methylphenyl)ketone수율 89.5%

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
80 °C

실험 절차

N-[2,2-Dimethyl-5-(2-{4-[5-(4-methylbenzoyl)-2-thienyl]phenyl}ethyl)-1,3-dioxan-5-yl]acetamide (0.22 g) was dissolved in ethanol (4 mL), concentrated hydrochloric acid (2 mL) was added, and the mixture was stirred at 80° C. for 4 hr. The reaction mixture was concentrated, aqueous potassium carbonate solution was added to the residue, and the precipitated crystals were collected by filtration to give the title compound (163 mg) as brown crystals.

후처리

  1. concentrationThe reaction mixture was concentrated
  2. additionaqueous potassium carbonate solution was added to the residue
  3. filtrationthe precipitated crystals were collected by filtration

출처 및 근거

ORD 기록
ord-a80e1ec1e9114f08b1287a4c7caea993
출처 데이터셋
uspto-grants-2012_02
특허 번호
US08114902B2

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