Water → 2-(4-Chloro-2-butenyl)-1,3-isoindolinedione

HRID 1642097

반응식

HRID 1642097 반응식
[Cl:1][CH2:2]/[CH:3]=[CH:4]/[CH2:5]Cl.[C:7]([NH2:18])(=[O:17])[C:8]1[C:9](=[CH:13][CH:14]=[CH:15][CH:16]=1)[C:10](N)=[O:11].[K].O>CN(C=O)C>[Cl:1][CH2:2][CH:3]=[CH:4][CH2:5][N:18]1[C:7](=[O:17])[C:8]2[C:9](=[CH:13][CH:14]=[CH:15][CH:16]=2)[C:10]1=[O:11]

참가 물질

5

반응물 3

HCID 962WaterHCID 6421971,4-Dichloro-2-butene, (2E)-HCID 53445390Potassium phthalamide

생성물 1

HCID 27342002-(4-Chloro-2-butenyl)-1,3-isoindolinedione수율 76%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

Trans-1,4-dichloro-2-butene (1.14 ml, 10.8 mmol) was dissolved in DMF (27 ml) and purged with argon. Potassium pthalamide (1.00 g, 5.40 mmol) was added to the solution and the reaction was allowed to stir at room temperature overnight. The reaction was then poured into water (75 ml), which precipitated a white solid. This solid was collected by filtration and purified using silica gel chromatography (3:1 Hex:EtOAc) to afford a 76% yield (961 mg) of a white solid.

후처리

  1. custompurged with argon
  2. customprecipitated a white solid
  3. filtrationThis solid was collected by filtration
  4. custompurified

출처 및 근거

ORD 기록
ord-f81910309c004b8eace99061811cd35d
출처 데이터셋
uspto-grants-2012_02
특허 번호
US08119642B2

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