Hydrochloric Acid → HCID 66755784, 화합물

HRID 1642146노트

반응식

HRID 1642146 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([S:9](Cl)(=[O:11])=[O:10])[CH:5]=[CH:6][C:7]=1[Cl:8].Cl.[CH3:14][O:15][C:16](=[O:24])[CH2:17][CH:18]1[CH2:23][CH2:22][CH2:21][CH2:20][NH:19]1.C(N(CC)CC)C.Cl>C(Cl)Cl>[Cl:1][C:2]1[CH:3]=[C:4]([S:9]([N:19]2[CH2:20][CH2:21][CH2:22][CH2:23][CH:18]2[CH2:17][C:16]([O:15][CH3:14])=[O:24])(=[O:11])=[O:10])[CH:5]=[CH:6][C:7]=1[Cl:8]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 7383Benzenesulfonyl chloride, 3,4-dichloro-HCID 8471TriethylamineHCID 13778732Methyl 2-(piperidin-2-yl)acetate hydrochloride

생성물 1

HCID 66755784HCID 66755784, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

A solution of 3,4-dichlorobenzenesulfonyl chloride (1.88 g, 7.65 mmol) in DCM (15 ml) was added at 0° C. to a solution, cooled to 0° C., of piperidin-2-ylacetic acid methyl ester hydrochloride (1.3 g, 8.4 mmol) in DCM (33 ml) and triethylamine (2.66 ml, 21 mmol), and stirring was then carried out for 90 minutes at room temperature. 0.5 M HCl (20 ml) was then added, and stirring was carried out for a further 15 minutes. The organic phase was separated off, washed with water and dried over sodium sulfate. The solvent was removed using a rotary evaporator and the product was used in the next stage without being purified further. Yield: 1.9 g (63%)

후처리

  1. stirringstirring
  2. waitwas carried out for a further 15 minutes
  3. customThe organic phase was separated off
  4. washwashed with water
  5. dry with materialdried over sodium sulfate
  6. customThe solvent was removed
  7. customa rotary evaporator
  8. customwithout being purified further

출처 및 근거

ORD 기록
ord-623a01e4931f4c1984e51264e9a356a6
출처 데이터셋
uspto-grants-2012_02
특허 번호
US08119633B2

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