Sodium Hydroxide → 2-[2-(4-methoxyphenyl)sulfonyl-3,4-dihydro-1H-isoquinolin-1-yl]acetic Acid

HRID 1642148노트

반응식

HRID 1642148 반응식
[OH-].[Na+].[CH3:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([S:11]([N:14]2[CH2:23][CH2:22][C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[CH:15]2[CH2:24][C:25]([O:27]C)=[O:26])(=[O:13])=[O:12])=[CH:7][CH:6]=1>C1COCC1.O>[CH3:3][O:4][C:5]1[CH:6]=[CH:7][C:8]([S:11]([N:14]2[CH2:23][CH2:22][C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[CH:15]2[CH2:24][C:25]([OH:27])=[O:26])(=[O:13])=[O:12])=[CH:9][CH:10]=1

참가 물질

5

반응물 2

HCID 14798Sodium HydroxideHCID 66756190HCID 66756190, 화합물

생성물 1

HCID 52638012-[2-(4-methoxyphenyl)sulfonyl-3,4-dihydro-1H-isoquinolin-1-yl]acetic Acid

시약·촉매·용매 2

HCID 962Water용매HCID 8028Tetrahydrofuran용매

실험 절차

A 6 M aqueous NaOH solution was added to a mixture of methyl 2-(2-(4-methoxyphenylsulfonyl)-1,2,3,4-tetrahydroisoquinolin-1-yl)acetate (15.22 g, 40.54 mmol) in THF (200 ml) and water (120 ml), and stirring was carried out overnight at room temperature. The solvent was then removed under reduced pressure, and a 6 M aqueous HCl solution (125 ml) and DCM (400 ml) were added. The phases were separated and then the organic phase was washed with concentrated NaCl solution, dried over sodium sulfate and concentrated. Yield: 14.65 g (100%)

후처리

  1. customThe solvent was then removed under reduced pressure
  2. additiona 6 M aqueous HCl solution (125 ml) and DCM (400 ml) were added
  3. customThe phases were separated
  4. washthe organic phase was washed with concentrated NaCl solution
  5. dry with materialdried over sodium sulfate
  6. concentrationconcentrated

출처 및 근거

ORD 기록
ord-03c334f4b2cc4e72bb6c7095db810294
출처 데이터셋
uspto-grants-2012_02
특허 번호
US08119633B2

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