Sodium Hydroxide → HCID 178507499, 화합물

HRID 1642334노트

반응식

HRID 1642334 반응식
C([O:4][C:5]([C:7]1[O:14][C:13]2[C:12]([NH:15][C:16](=[O:26])[C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=3[N+:23]([O-])=O)=[N:11][N:10](C(OCC)=O)[C:9]=2[CH:8]=1)=[O:6])CC.[OH-].[Na+]>CO>[NH2:23][C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][C:17]=1[C:16]([NH:15][C:12]1[NH:11][N:10]=[C:9]2[CH:8]=[C:7]([C:5]([OH:6])=[O:4])[O:14][C:13]=12)=[O:26]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 578786493-(2-Nitro-benzoylamino)-furo[3,2-c]pyrazole-1,5-dicarboxylic acid 1-ethyl ester 5-propyl ester

생성물 1

HCID 178507499HCID 178507499, 화합물수율 129%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of 3-(2-Nitro-benzoylamino)-furo[3,2-c]pyrazole-1,5-dicarboxylic acid 1-ethyl ester 5-propyl ester (7.6 g, 0.0176 mol) in methanol (100 mL), NaOH 2N (44.1 mL, 0.0882 mmol) was added. The mixture was gently refluxed for 8 hours, then the solvent was evaporated under vacuum, and the residual aqueous solution was diluted with water and ice. Hydrochloric acid (12 N) was added until pH 2. The yellowish solid that precipitated was collected, washed with water and dried under vacuum at 60° C. 6.5 g of the title compound was so obtained.

후처리

  1. temperatureThe mixture was gently refluxed for 8 hours
  2. customthe solvent was evaporated under vacuum
  3. additionthe residual aqueous solution was diluted with water and ice
  4. additionHydrochloric acid (12 N) was added until pH 2
  5. customThe yellowish solid that precipitated was collected
  6. washwashed with water
  7. customdried under vacuum at 60° C

출처 및 근거

ORD 기록
ord-4643ff21cfc143c085204e3c795e16b7
출처 데이터셋
uspto-grants-2012_02
특허 번호
US08119641B2

반응 노트

불러오는 중…