Ethyl Acetate → 4-(4-Amino-2-chlorophenoxy)-2-fluorobenzonitrile

HRID 16426

반응식

HRID 16426 반응식
[F:1][C:2]1[CH:9]=[C:8](F)[CH:7]=[CH:6][C:3]=1[C:4]#[N:5].[Cl:11][C:12]1[CH:13]=[C:14]([CH:16]=[CH:17][C:18]=1[OH:19])[NH2:15].C(=O)([O-])[O-].[K+].[K+].C(OCC)(=O)C>C(#N)C>[NH2:15][C:14]1[CH:16]=[CH:17][C:18]([O:19][C:8]2[CH:7]=[CH:6][C:3]([C:4]#[N:5])=[C:2]([F:1])[CH:9]=2)=[C:12]([Cl:11])[CH:13]=1

참가 물질

6

반응물 4

HCID 8857Ethyl AcetateHCID 11430Potassium CarbonateHCID 775452,4-DifluorobenzonitrileHCID 775784-Amino-2-chlorophenol

생성물 1

HCID 179793474-(4-Amino-2-chlorophenoxy)-2-fluorobenzonitrile

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

2.00 g (14.4 mmol) of 2,4-difluorobenzonitrile, 2.06 g (14.4 mmol) of 3-chloro-4-hydroxyaniline and 3.97 g (28.8 mmol) of potassium carbonate in 20 ml of acetonitrile are heated at RF for one hour. Ethyl acetate is added, the mixture is filtered and the solvent is removed under reduced pressure. The residue is purified by column chromatography (silica gel 60), giving the product which is a regioisomer mixture with a ratio of 62:38.

후처리

  1. filtrationthe mixture is filtered
  2. customthe solvent is removed under reduced pressure
  3. customThe residue is purified by column chromatography (silica gel 60)
  4. customgiving the product which

출처 및 근거

ORD 기록
ord-469b7561ac284cd882eeac1cf9b3c0ae
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07737153B2

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