Benzoyl chloride → HCID 59850297, 화합물

HRID 1642647노트

반응식

HRID 1642647 반응식
[CH2:1]([C:8]1[CH:13]=[CH:12][C:11]([N:14]2[S:18](=[O:20])(=[O:19])[NH:17][C:16](=[O:21])[CH2:15]2)=[C:10]([OH:22])[CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.CC([O-])(C)C.[K+].[C:29](Cl)(=[O:36])[C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1>CN(C=O)C>[CH2:1]([C:8]1[CH:13]=[CH:12][C:11]([N:14]2[CH2:15][C:16](=[O:21])[NH:17][S:18]2(=[O:20])=[O:19])=[C:10]([O:22][C:29](=[O:36])[C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)[CH:9]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

5

반응물 3

HCID 7412Benzoyl chlorideHCID 23665647Potassium tert-butoxideHCID 24895697HCID 24895697, 화합물

생성물 1

HCID 59850297HCID 59850297, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

To a solution of 5-(4-benzyl-2-hydroxyphenyl)-1,1-dioxo-1,2,5-thiadiazolidin-3-one (45 mg, 0.141 mmol) in DMF (0.2 mL) is added KOtBu (1.0 M in THF, 0.17 mL, 0.17 mmol). After it is stirred at ambient temperature for 5 min., benzoyl chloride (35 mg, 0.254 mmol) is added. After it is stirred at ambient temperature for 10 min., the reaction is quenched with 1N HCl solution. The residue is then purified by prep. HPLC using CH3CN (0.1% TFA)/water (5-70%) to give the title compound: MS (M−H)−=421.

후처리

  1. stirringAfter it is stirred at ambient temperature for 10 min.
  2. customthe reaction is quenched with 1N HCl solution
  3. customThe residue is then purified by prep

출처 및 근거

ORD 기록
ord-906de45988364db09f1bce0f8b8c9968
출처 데이터셋
uspto-grants-2012_02
특허 번호
US08119666B2

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