Hydroxylamine HCl → 3,4-difluoro-N'-hydroxybenzenecarboximidamide
반응식
[F:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[F:10])[C:5]#[N:6].[Cl-].[OH:12][NH3+:13].C(=O)(O)[O-].[Na+]>C(O)C.O>[F:1][C:2]1[CH:3]=[C:4]([C:5](=[N:13][OH:12])[NH2:6])[CH:7]=[CH:8][C:9]=1[F:10]참가 물질
6
실험 절차
1.0 g (7.2 mmol) of 3,4-difluorobenzonitrile was initially charged in 30 ml of ethanol, and a solution of 0.5 g (7.2 mmol) of hydroxylammonium chloride and 0.6 g (7.2 mmol) of sodium bicarbonate in 11 ml of water was added at RT. The reaction mixture was stirred at RT for 16 h, concentrated under reduced pressure and reacted without further purification.
후처리
- concentrationconcentrated under reduced pressure
- customreacted without further purification
출처 및 근거
- ORD 기록
- ord-f318a85fe057494a808fb1f517fdf0ad
- 출처 데이터셋
- uspto-grants-2012_02
- 특허 번호
- US08119663B2
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