Hydrochloric Acid → N-{4-[(3-Amino-1,2-benzisoxazol-4-yl)oxy]-3-fluorophenyl}-N-[2-amino-6-(4-pyridinyl)-4-pyrimidinyl]amine

HRID 16433노트

반응식

HRID 16433 반응식
[NH2:1][C:2]1[CH:18]=[CH:17][C:5]([O:6][C:7]2[C:12]3[C:13]([NH2:16])=[N:14][O:15][C:11]=3[CH:10]=[CH:9][CH:8]=2)=[C:4]([F:19])[CH:3]=1.Cl[C:21]1[CH:26]=[C:25]([C:27]2[CH:32]=[CH:31][N:30]=[CH:29][CH:28]=2)[N:24]=[C:23]([NH2:33])[N:22]=1.Cl>O>[NH2:16][C:13]1[C:12]2[C:7]([O:6][C:5]3[CH:17]=[CH:18][C:2]([NH:1][C:21]4[CH:26]=[C:25]([C:27]5[CH:32]=[CH:31][N:30]=[CH:29][CH:28]=5)[N:24]=[C:23]([NH2:33])[N:22]=4)=[CH:3][C:4]=3[F:19])=[CH:8][CH:9]=[CH:10][C:11]=2[O:15][N:14]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 179792974-(4-Amino-2-fluorophenoxy)-1,2-benzisoxazole-3-amineHCID 223242864-Chloro-6-(pyridin-4-yl)pyrimidin-2-amine

생성물 1

HCID 17979269N-{4-[(3-Amino-1,2-benzisoxazol-4-yl)oxy]-3-fluorophenyl}-N-[2-amino-6-(4-pyridinyl)-4-pyrimidinyl]amine

시약·촉매·용매 1

HCID 962Water용매

실험 절차

70 mg (0.27 mmol) of 4-(4-amino-2-fluorophenoxy)-1,2-benzisoxazole-3-amine (from example VII) and 55.8 mg (0.27 mmol) of 4-chloro-6-(4-pyridinyl)-2-pyrimidineamine (from example XXIX) are suspended in 4 ml of water, and 0.02 ml of concentrated hydrochloric acid is added. The reaction mixture is heated at reflux overnight, resulting in the formation of a lightly colored precipitate. This is filtered off, washed repeatedly with water and dried under high vacuum.

후처리

  1. temperatureThe reaction mixture is heated
  2. temperatureat reflux overnight
  3. customresulting in the formation of a lightly colored precipitate
  4. filtrationThis is filtered off
  5. washwashed repeatedly with water
  6. customdried under high vacuum

출처 및 근거

ORD 기록
ord-61b7c47c928949d9baad30b4fe9e65b1
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07737153B2

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